MYH14

Across TCGA pan-cancer cohorts, MYH14 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated MYH14 data layer compared with 27 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher MYH14 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MYH14 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

THYM, UCEC, and DLBC are the cancer types where MYH14 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	All	0.604	0.975	<.001	30	view →
UCEC	DFS	Median	II,III,IV	0.902	0.431	.012	24	view →
DLBC	DFS	Median	II,III,IV	0.065	0.829	<.001	20	view →
KIRC	DFS	Median	All	0.190	0.628	.011	8	view →
SARC	DFS	Median	All	0.144	0.603	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LIHC	OS	Median	II,III,IV	0.247	0.718	.004	6	view →
SKCM	OS	Median	II,III,IV	0.962	0.831	.016	5	view →
LUSC	DFS	Median	II,III,IV	0.269	0.711	.012	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
STAD	DFS	Median	All	0.817	0.377	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

MYH14–THYM (OS)

Open the THYM breakdown →