MYH14

Across TCGA patient cohorts, MYH14 mutation is significantly associated with the RNA expression of many other genes, with 4,877 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYH14-associated genes across cancer lineages are RAI2, CENPU, and SLBP. Each is linked with MYH14 in more than 4 cancer types. Because this analysis shows association rather than direction, both MYH14-to-partner and partner-to-MYH14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAI2 grouped by MYH14-low versus MYH14-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH14→partner) and Y-score (partner→MYH14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RAI2 →	-0.609	-1.807	.009	.004	3	5
STAD	CENPU →	+0.857	+3.601	<.001	.001	3	4
UCEC	SLBP →	+0.405	+2.410	<.001	<.001	3	4
UCEC	GLOD4 →	+0.371	+1.502	<.001	<.001	3	4
UCEC	PBK →	+0.652	+1.382	<.001	<.001	3	4
UCEC	PDGFD →	-0.526	-2.159	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,877 associations by consensus.

RAI2 by MYH14 expression — COAD

Explore this box plot interactively →