MYH14

Across TCGA cell cohorts, MYH14 mutation is significantly associated with the RNA expression of many other genes, with 2,140 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYH14-associated genes across cancer lineages are DESI1, PCSK4, and DYNC2LI1. Each is linked with MYH14 in more than 2 cancer types. Because this analysis shows association rather than direction, both MYH14-to-partner and partner-to-MYH14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DESI1 grouped by MYH14-low versus MYH14-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH14→partner) and Y-score (partner→MYH14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DESI1 →	+0.581	+3.459	<.001	<.001	3	3
LARGE_INTESTINE	PCSK4 →	+0.798	+1.949	<.001	.002	3	3
LARGE_INTESTINE	DYNC2LI1 →	+0.497	+2.649	<.001	.001	3	3
LARGE_INTESTINE	LYG1 →	+1.036	+2.458	<.001	<.001	3	3
LARGE_INTESTINE	ACADSB →	+0.670	+1.949	<.001	.002	3	3
BLOOD_Leukemia	MND1 →	+0.745	+3.730	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,140 associations by consensus.

DESI1 by MYH14 expression — LARGE_INTESTINE

Explore this box plot interactively →