MYH11

Across TCGA patient cohorts, MYH11 protein abundance is significantly associated with the RNA expression of many other genes, with 11,783 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MYH11-associated genes across cancer lineages are CASQ2, AOC3, and ADH1B. Each is linked with MYH11 in more than 9 cancer types. Because this analysis shows association rather than direction, both MYH11-to-partner and partner-to-MYH11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MYH11 versus CASQ2 in HNSC, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH11→partner) and Y-score (partner→MYH11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CASQ2 →	+2.190	+0.646	<.001	.001	3	10
BRCA	AOC3 →	+1.473	+1.034	<.001	<.001	3	10
CCRCC	ADH1B →	+1.982	+1.054	<.001	<.001	3	10
OV	PLN →	+1.919	+0.951	<.001	<.001	3	10
UCEC	ACTA2 →	+1.564	+0.994	<.001	<.001	3	9
CCRCC	MGP →	+1.698	+1.042	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,783 associations by consensus.

MYH11 vs CASQ2 — HNSC

Explore this scatter interactively →