MYH11

Across TCGA patient cohorts, MYH11 mutation is significantly associated with the RNA expression of many other genes, with 7,855 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYH11-associated genes across cancer lineages are NCAPG, CCNB1, and ORC1. Each is linked with MYH11 in more than 5 cancer types. Because this analysis shows association rather than direction, both MYH11-to-partner and partner-to-MYH11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCAPG grouped by MYH11-low versus MYH11-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH11→partner) and Y-score (partner→MYH11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NCAPG →	+1.026	+3.830	<.001	<.001	3	6
LUAD	CCNB1 →	+0.819	+2.274	<.001	<.001	3	6
LUAD	ORC1 →	+0.866	+1.874	<.001	.002	3	6
UCEC	TAF9 →	+0.533	+1.765	<.001	<.001	3	5
BRCA	DLGAP5 →	+1.171	+3.338	<.001	.005	3	5
BRCA	DTL →	+0.957	+3.338	.003	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,855 associations by consensus.

NCAPG by MYH11 expression — LUAD

Explore this box plot interactively →