MYH11

Across TCGA cell cohorts, MYH11 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,071 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MYH11-associated GO terms across cancer lineages are DNA double-strand break processing involved in repair via single-strand annealing, Double-strand break repair via single-strand annealing, and Regulation of organelle assembly. Each is linked with MYH11 in more than 8 cancer types. Because this analysis shows association rather than direction, both MYH11-to-partner and partner-to-MYH11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA double-strand break processing involved in repair via single-strand annealing grouped by MYH11-low versus MYH11-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH11→partner) and Y-score (partner→MYH11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DNA double-strand break processing involved in repair via single-strand annealing →	+0.083	+1.087	<.001	<.001	3	8
BLOOD_Lymphoma	Double-strand break repair via single-strand annealing →	+0.083	+1.087	<.001	<.001	3	8
LUNG_NSCLC_LUSC	Regulation of organelle assembly →	+0.063	+0.279	<.001	<.001	2	9
LUNG_SCLC	Negative regulation of organelle assembly →	+0.073	+0.347	<.001	.002	3	8
SOFT_TISSUE	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.128	+0.647	<.001	<.001	3	8
BLOOD_Leukemia	Regulation of nucleotide-excision repair →	+0.095	+0.505	<.001	<.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,071 associations by consensus.

DNA double-strand break processing involved in repair via single-strand annealing by MYH11 expression — BLOOD_Lymphoma

Explore this box plot interactively →