MYH11

Across TCGA cell cohorts, MYH11 mutation is significantly associated with the RNA expression of many other genes, with 808 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYH11-associated genes across cancer lineages are OR2L8, RHOH, and FOXF2. Each is linked with MYH11 in more than 2 cancer types. Because this analysis shows association rather than direction, both MYH11-to-partner and partner-to-MYH11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2L8 grouped by MYH11-low versus MYH11-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH11→partner) and Y-score (partner→MYH11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	OR2L8 →	+0.020	+4.169	<.001	.008	3	2
SKIN	RHOH →	+0.121	+3.192	.001	.007	3	2
BLOOD_Leukemia	FOXF2 →	+0.278	+2.994	.005	.002	3	2
BLOOD_Leukemia	ANAPC16 →	+0.639	+3.175	.002	.009	3	2
BLOOD_Leukemia	B4GALNT2 →	+0.017	+2.966	<.001	.003	3	2
BLOOD_Leukemia	KSR2 →	+0.287	+3.955	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 808 associations by consensus.

OR2L8 by MYH11 expression — BONE

Explore this box plot interactively →