MYH10

Across TCGA patient cohorts, MYH10 mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYH10-associated genes across cancer lineages are p38-MAPK_pT180_Y182, ATM, and eIF4E. Each is linked with MYH10 in more than 3 cancer types. Because this analysis shows association rather than direction, both MYH10-to-partner and partner-to-MYH10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by MYH10-low versus MYH10-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH10→partner) and Y-score (partner→MYH10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	p38-MAPK_pT180_Y182 →	-0.358	-2.986	.030	.037	3	4
UCEC	ATM →	-0.469	-1.584	<.001	<.001	3	4
COAD	eIF4E →	+0.234	+2.820	.007	.035	3	3
STAD	FASN →	+0.510	+2.459	.004	.019	3	3
BLCA	Smad3 →	+0.139	+2.999	.039	.035	3	3
UCEC	Cyclin-B1 →	+0.621	+1.584	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

p38-MAPK_pT180_Y182 by MYH10 expression — BRCA

Explore this box plot interactively →