MYH10

Across TCGA cell cohorts, MYH10 mutation is significantly associated with the RNA expression of many other genes, with 983 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYH10-associated genes across cancer lineages are METTL4, TBC1D12, and OCIAD1. Each is linked with MYH10 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYH10-to-partner and partner-to-MYH10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, METTL4 grouped by MYH10-low versus MYH10-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH10→partner) and Y-score (partner→MYH10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	METTL4 →	+0.655	+2.743	<.001	.001	3	2
LARGE_INTESTINE	TBC1D12 →	+0.698	+2.386	.001	.007	3	2
LARGE_INTESTINE	OCIAD1 →	+0.468	+3.295	<.001	.003	3	2
LARGE_INTESTINE	DCLRE1B →	+0.520	+2.743	.002	.001	3	2
LARGE_INTESTINE	ALDH6A1 →	+1.130	+3.459	<.001	<.001	3	2
LARGE_INTESTINE	TRIM45 →	+0.632	+2.743	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 983 associations by consensus.

METTL4 by MYH10 expression — LARGE_INTESTINE

Explore this box plot interactively →