MYF6

Across TCGA pan-cancer cohorts, MYF6 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated MYF6 data layer compared with 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MYF6 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MYF6 expression acts as an unfavorable survival marker, although some lineages such as PAAD and UCS show a favorable association.

HNSC, KIRP, and KIRC are the cancer types where MYF6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.683	0.801	<.001	94	view →
KIRP	OS	Tertile	All	0.450	0.769	<.001	76	view →
KIRC	OS	Tertile	All	0.509	0.683	<.001	60	view →
DLBC	OS	Quartile	II,III,IV	0.652	0.983	<.001	55	view →
LIHC	OS	Quartile	All	0.659	0.826	<.001	42	view →
PAAD	DFS	Tertile	All	0.390	0.230	.009	41	view →
THCA	OS	Tertile	II,III,IV	0.852	0.991	<.001	34	view →
COAD	OS	Tertile	II,III,IV	0.726	0.873	.016	27	view →
SCLC	OS	Tertile	IV	0.164	0.599	.001	24	view →
STAD	DFS	Quartile	All	0.497	0.676	.002	20	view →
UCS	DFS	Median	II,III,IV	0.592	0.287	.011	18	view →
MESO	DFS	Tertile	All	0.134	0.568	.005	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

MYF6–HNSC (OS)

Open the HNSC breakdown →