MYDGF

Across TCGA patient cohorts, MYDGF mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYDGF-associated genes across cancer lineages are Ku80, Notch1, and PDCD4. Each is linked with MYDGF in more than 1 cancer types. Because this analysis shows association rather than direction, both MYDGF-to-partner and partner-to-MYDGF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by MYDGF-low versus MYDGF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYDGF→partner) and Y-score (partner→MYDGF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.302	+2.817	.027	.036	3	1
UCEC	Notch1 →	+0.218	+2.820	.007	.035	3	1
UCEC	PDCD4 →	-0.696	-3.000	.010	.037	3	1
UCEC	AMPK_pT172 →	+0.500	+3.013	.035	.019	3	1
UCEC	Annexin-1 →	+0.927	+3.000	.002	.037	1	1
UCEC	Cyclin-B1 →	+0.868	+3.000	.007	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Ku80 by MYDGF expression — UCEC

Explore this box plot interactively →