MYD88

Across TCGA cell cohorts, MYD88 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,587 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MYD88-associated GO terms across cancer lineages are Toll-like receptor 8 signaling pathway, Positive regulation of interleukin-23 production, and Rho protein signal transduction. Each is linked with MYD88 in more than 18 cancer types. Because this analysis shows association rather than direction, both MYD88-to-partner and partner-to-MYD88 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Toll-like receptor 8 signaling pathway grouped by MYD88-low versus MYD88-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MYD88→partner) and Y-score (partner→MYD88) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Toll-like receptor 8 signaling pathway →	+1.485	+2.611	<.001	<.001	3	19
KIDNEY	Positive regulation of interleukin-23 production →	+1.228	+1.296	<.001	.003	3	15
CNS	Rho protein signal transduction →	+0.086	+1.703	<.001	<.001	3	13
LUNG_SCLC	Canonical inflammasome complex assembly →	+0.157	+1.158	<.001	<.001	3	13
LUNG_SCLC	Inflammasome-mediated signaling pathway →	+0.157	+1.158	<.001	<.001	3	13
SOFT_TISSUE	Interferon-mediated signaling pathway →	+0.098	+1.558	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,587 associations by consensus.

Toll-like receptor 8 signaling pathway by MYD88 expression — SOFT_TISSUE

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