MYD88

Across TCGA cell cohorts, MYD88 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYD88-associated genes across cancer lineages are MORC1, OR1E2, and LIPK. Each is linked with MYD88 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYD88-to-partner and partner-to-MYD88 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MORC1 grouped by MYD88-low versus MYD88-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYD88→partner) and Y-score (partner→MYD88) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MORC1 →	+0.072	+4.350	.006	.005	3	1
BLOOD_Lymphoma	OR1E2 →	+0.012	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	LIPK →	+0.134	+4.927	<.001	.001	3	1
BLOOD_Lymphoma	SPANXN2 →	+0.149	+4.643	<.001	.005	3	1
LARGE_INTESTINE	PLVAP →	+0.230	+3.539	<.001	.004	3	1
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MORC1 by MYD88 expression — BLOOD_Lymphoma

Explore this box plot interactively →