MYCNOS

Across TCGA pan-cancer cohorts, MYCNOS RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated MYCNOS data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MYCNOS RNA is associated with better overall survival. In most high-consensus cancer types, elevated MYCNOS expression acts as an unfavorable survival marker, although some lineages such as HNSC and OV show a favorable association.

HNSC, UVM, and OV are the cancer types where MYCNOS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	IV	0.564	0.257	<.001	123	view →
UVM	OS	Median	All	0.412	0.773	<.001	109	view →
OV	OS	Median	III,IV	0.745	0.622	<.001	94	view →
UCS	DFS	Median	II,III,IV	0.558	0.182	.002	62	view →
LGG	OS	Tertile	All	0.516	0.368	.002	32	view →
LUSC	DFS	Quartile	III,IV	0.092	1.000	.006	23	view →
ESCA	OS	Tertile	III,IV	0.601	0.272	.002	19	view →
ACC	DFS	Tertile	All	0.398	0.640	.011	14	view →
MESO	OS	Quartile	IV	0.286	0.798	.026	12	view →
READ	OS	Quartile	IV	0.975	0.506	.013	12	view →
PAAD	OS	Tertile	All	0.782	0.526	.009	12	view →
BRCA	DFS	Quartile	III,IV	0.821	0.904	.019	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

MYCNOS–HNSC (OS)

Open the HNSC breakdown →