MYCN

Across TCGA patient cohorts, MYCN RNA expression is significantly associated with the protein abundance of many other proteins, with 16,892 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MYCN-associated proteins across cancer lineages are PLCB4, CASP4, and FKBP5. Each is linked with MYCN in more than 4 cancer types. Because this analysis shows association rather than direction, both MYCN-to-partner and partner-to-MYCN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MYCN versus PLCB4 in HNSC, with a Pearson correlation of 0.50.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MYCN→partner) and Y-score (partner→MYCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PLCB4 →	+0.627	+1.453	<.001	<.001	3	5
HNSC	CASP4 →	-0.557	-1.019	<.001	.003	3	5
UCEC	FKBP5 →	-0.754	-1.832	.001	<.001	3	5
GBM	SERPINB1 →	-0.540	-0.968	<.001	<.001	3	5
GBM	CENPV →	+0.947	+1.169	<.001	<.001	3	5
UCEC	UGGT1 →	+0.304	+1.920	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,892 associations by consensus.

MYCN vs PLCB4 — HNSC

Explore this scatter interactively →