MYCN

Across TCGA patient cohorts, MYCN protein abundance is significantly associated with the RNA expression of many other genes, with 573 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible MYCN-associated genes across cancer lineages are MIR6077, ZFYVE21, and EBI3. Each is linked with MYCN in more than 1 cancer types. Because this analysis shows association rather than direction, both MYCN-to-partner and partner-to-MYCN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MYCN versus MIR6077 in HNSC, with a Pearson correlation of 0.67.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYCN→partner) and Y-score (partner→MYCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR6077 →	+1.752	+1.048	<.001	<.001	3	2
LSCC	ZFYVE21 →	-0.592	-0.766	<.001	<.001	3	1
LSCC	EBI3 →	+0.956	+0.908	.003	.004	3	1
LSCC	PLPPR2 →	-0.598	-0.950	.004	.002	3	1
LSCC	IMPDH1 →	-0.933	-0.705	<.001	<.001	3	1
LSCC	CLTA →	-0.960	-0.565	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 573 associations by consensus.

MYCN vs MIR6077 — HNSC

Explore this scatter interactively →