MYCN

Across TCGA patient cohorts, MYCN mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. COAD shows the largest number of these associations.

The most reproducible MYCN-associated genes across cancer lineages are GMP, Chondrocytes, and MPP. Each is linked with MYCN in more than 1 cancer types. Because this analysis shows association rather than direction, both MYCN-to-partner and partner-to-MYCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GMP grouped by MYCN-low versus MYCN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYCN→partner) and Y-score (partner→MYCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GMP →	+0.035	+1.484	<.001	.045	3	2
LUSC	Chondrocytes →	+0.008	+3.109	.047	.043	3	1
COAD	MPP →	+0.023	+3.140	.004	.006	3	1
STAD	NK cells →	+0.011	+5.597	<.001	.040	3	1
UCEC	Erythrocytes →	+0.020	+2.818	.038	.035	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

GMP by MYCN expression — SKCM

Explore this box plot interactively →