MYCN

Across TCGA cell cohorts, MYCN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,145 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MYCN-associated GO terms across cancer lineages are Morphogenesis of an epithelial fold, Negative regulation of mRNA catabolic process, and Positive regulation of amine metabolic process. Each is linked with MYCN in more than 7 cancer types. Because this analysis shows association rather than direction, both MYCN-to-partner and partner-to-MYCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Morphogenesis of an epithelial fold grouped by MYCN-low versus MYCN-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MYCN→partner) and Y-score (partner→MYCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Morphogenesis of an epithelial fold →	+1.549	+1.386	<.001	<.001	3	8
OVARY	Negative regulation of mRNA catabolic process →	+0.073	+2.465	<.001	<.001	3	8
OVARY	Positive regulation of amine metabolic process →	-0.171	-1.950	.003	.001	3	7
BONE	Positive regulation of keratinocyte differentiation →	+0.208	+1.354	<.001	<.001	3	7
BONE	Regulation of glucose mediated signaling pathway →	+0.106	+1.463	<.001	.001	3	7
BONE	Positive regulation of glucose mediated signaling pathway →	+0.106	+1.463	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,145 associations by consensus.

Morphogenesis of an epithelial fold by MYCN expression — OVARY

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