MYCN

Across TCGA cell cohorts, MYCN mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYCN-associated genes across cancer lineages are KRTAP6-1, CCT8L2, and OR6C3. Each is linked with MYCN in more than 1 cancer types. Because this analysis shows association rather than direction, both MYCN-to-partner and partner-to-MYCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP6-1 grouped by MYCN-low versus MYCN-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYCN→partner) and Y-score (partner→MYCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KRTAP6-1 →	+0.075	+5.022	<.001	.002	3	1
SKIN	CCT8L2 →	+0.065	+5.022	<.001	.002	3	1
SKIN	OR6C3 →	+0.016	+4.415	<.001	.007	3	1
SKIN	AKAIN1 →	+0.085	+4.930	<.001	.001	3	1
SKIN	CT45A6 →	+0.082	+4.095	.006	.009	3	1
SKIN	NCR2 →	+0.015	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

KRTAP6-1 by MYCN expression — SKIN

Explore this box plot interactively →