MYCN

Across TCGA cell cohorts, MYCN mutation is significantly associated with the mutation status of many other genes, with 5,369 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYCN-associated genes across cancer lineages are DLGAP1, FOXN3, and ZFR. Each is linked with MYCN in more than 4 cancer types. Because this analysis shows association rather than direction, both MYCN-to-partner and partner-to-MYCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DLGAP1 grouped by MYCN-low versus MYCN-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYCN→partner) and Y-score (partner→MYCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DLGAP1 →	+4.562	+5.217	<.001	<.001	1	5
OVARY	FOXN3 →	+4.977	+4.415	.007	.007	1	5
OVARY	ZFR →	+4.977	+4.415	.007	.007	1	5
LARGE_INTESTINE	TDRD12 →	+2.584	+3.182	<.001	<.001	1	5
LARGE_INTESTINE	ADGRA2 →	+2.129	+2.504	.007	.007	1	5
BLOOD_Lymphoma	EDEM2 →	+5.247	+4.429	.005	.005	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,369 associations by consensus.

DLGAP1 by MYCN expression — OVARY

Explore this box plot interactively →