MYCL

Across TCGA patient cohorts, MYCL mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYCL-associated genes across cancer lineages are C-Raf, Heregulin, and Ku80. Each is linked with MYCL in more than 1 cancer types. Because this analysis shows association rather than direction, both MYCL-to-partner and partner-to-MYCL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by MYCL-low versus MYCL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYCL→partner) and Y-score (partner→MYCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.151	+3.321	.044	.010	3	2
UCEC	Heregulin →	-0.147	-3.169	.023	.019	3	1
UCEC	Ku80 →	+0.358	+2.183	.003	.035	3	1
UCEC	p70-S6K →	+0.202	+2.196	.045	.034	3	1
UCEC	PDK1_pS241 →	+0.254	+2.833	.004	.034	3	1
UCEC	PRAS40_pT246 →	+0.177	+2.183	.049	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

C-Raf by MYCL expression — UCEC

Explore this box plot interactively →