MYCBP2

Across TCGA patient cohorts, MYCBP2 mutation is significantly associated with the total protein of many other genes, with 123 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYCBP2-associated genes across cancer lineages are Cyclin-B1, PKC-delta_pS664, and Caspase-7-cleavedD198. Each is linked with MYCBP2 in more than 4 cancer types. Because this analysis shows association rather than direction, both MYCBP2-to-partner and partner-to-MYCBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by MYCBP2-low versus MYCBP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYCBP2→partner) and Y-score (partner→MYCBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.615	+1.772	<.001	<.001	3	5
COAD	PKC-delta_pS664 →	-0.085	-1.354	.046	.035	3	5
COAD	Caspase-7-cleavedD198 →	+1.644	+2.882	<.001	<.001	3	5
STAD	FoxM1 →	+0.372	+2.662	<.001	<.001	3	4
COAD	ATM →	-0.490	-1.678	<.001	.018	3	4
STAD	4E-BP1 →	+0.302	+1.765	.002	.012	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 123 associations by consensus.

Cyclin-B1 by MYCBP2 expression — UCEC

Explore this box plot interactively →