MYCBP2

Across TCGA cell cohorts, MYCBP2 mutation is significantly associated with the RNA expression of many other genes, with 2,404 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYCBP2-associated genes across cancer lineages are PDXP, ENPP4, and KRTAP7-1. Each is linked with MYCBP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MYCBP2-to-partner and partner-to-MYCBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDXP grouped by MYCBP2-low versus MYCBP2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYCBP2→partner) and Y-score (partner→MYCBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PDXP →	+0.823	+3.570	.003	<.001	3	3
BLOOD_Leukemia	ENPP4 →	+1.018	+3.115	.007	.009	3	3
BLOOD_Leukemia	KRTAP7-1 →	+0.026	+2.954	<.001	.005	3	3
BREAST	POPDC2 →	+0.514	+3.152	<.001	.009	3	3
LARGE_INTESTINE	DYNLRB1 →	-0.564	-2.989	.002	.007	3	3
LARGE_INTESTINE	FITM1 →	+0.228	+1.491	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,404 associations by consensus.

PDXP by MYCBP2 expression — LUNG_SCLC

Explore this box plot interactively →