MYCBP2

Across TCGA cell cohorts, MYCBP2 mutation is significantly associated with the mutation status of many other genes, with 6,033 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYCBP2-associated genes across cancer lineages are SYNE2, TLN2, and F8. Each is linked with MYCBP2 in more than 7 cancer types. Because this analysis shows association rather than direction, both MYCBP2-to-partner and partner-to-MYCBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYNE2 grouped by MYCBP2-low versus MYCBP2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYCBP2→partner) and Y-score (partner→MYCBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SYNE2 →	+2.173	+2.584	.002	.002	1	8
BLOOD_Leukemia	TLN2 →	+2.452	+2.658	<.001	<.001	1	7
OVARY	F8 →	+2.994	+1.962	.006	.006	1	7
SOFT_TISSUE	BCL9 →	+4.562	+3.329	.003	.003	1	6
BLOOD_Lymphoma	PIK3C2A →	+4.016	+3.162	.001	.001	1	6
OVARY	PRRC2C →	+2.672	+1.951	.004	.004	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,033 associations by consensus.

SYNE2 by MYCBP2 expression — CNS

Explore this box plot interactively →