MYC

Across TCGA pan-cancer cohorts, MYC Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MYC data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MYC Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MYC expression acts as an unfavorable survival marker, although some lineages such as MESO show a favorable association.

HNSC, DLBC, and LIHC are the cancer types where MYC Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.029	0.712	<.001	24	view →
DLBC	DFS	Median	All	0.022	0.809	<.001	18	view →
LIHC	OS	Median	All	0.031	0.777	<.001	12	view →
UCEC	OS	Median	IV	0.270	0.790	.001	12	view →
MESO	DFS	Median	All	1.000	0.179	.041	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MYC–HNSC (OS)

Open the HNSC breakdown →