MYC

Across TCGA patient cohorts, MYC protein abundance is significantly associated with the RNA expression of many other genes, with 4,511 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MYC-associated genes across cancer lineages are H2AZ1, DNAJC2, and UTP25. Each is linked with MYC in more than 2 cancer types. Because this analysis shows association rather than direction, both MYC-to-partner and partner-to-MYC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MYC versus H2AZ1 in LUAD, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYC→partner) and Y-score (partner→MYC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	H2AZ1 →	+0.915	+1.647	<.001	<.001	3	3
HNSC	DNAJC2 →	+0.618	+0.496	<.001	.001	3	3
HNSC	UTP25 →	+0.610	+0.436	.002	.003	3	3
BRCA	HELLS →	+0.940	+1.321	<.001	<.001	3	3
HNSC	NDUFAF4 →	+0.795	+0.403	.005	.006	3	3
HNSC	TEX10 →	+0.638	+0.555	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,511 associations by consensus.

MYC vs H2AZ1 — LUAD

Explore this scatter interactively →