MYC

Across TCGA patient cohorts, MYC protein abundance is significantly associated with the protein abundance of many other proteins, with 8,082 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MYC-associated proteins across cancer lineages are AP3B1, ATN1, and ACTR1A. Each is linked with MYC in more than 3 cancer types. Because this analysis shows association rather than direction, both MYC-to-partner and partner-to-MYC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MYC versus AP3B1 in BRCA, with a Pearson correlation of -0.44.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MYC→partner) and Y-score (partner→MYC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AP3B1 →	-0.380	-0.891	<.001	<.001	3	4
BRCA	ATN1 →	+0.534	+1.464	.001	<.001	3	3
HNSC	ACTR1A →	-0.506	-0.560	<.001	<.001	3	3
BRCA	BYSL →	+0.419	+0.927	<.001	<.001	3	3
HNSC	CAPNS1 →	-0.556	-0.714	<.001	<.001	3	3
HNSC	COMMD8 →	-0.401	-0.662	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,082 associations by consensus.

MYC vs AP3B1 — BRCA

Explore this scatter interactively →