MYC

Across TCGA patient cohorts, MYC mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYC-associated genes across cancer lineages are eIF4G, A-Raf_pS299, and FoxM1. Each is linked with MYC in more than 1 cancer types. Because this analysis shows association rather than direction, both MYC-to-partner and partner-to-MYC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by MYC-low versus MYC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYC→partner) and Y-score (partner→MYC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.242	+1.874	.037	.049	3	1
UCEC	A-Raf_pS299 →	-0.145	-2.807	.001	.003	3	1
UCEC	FoxM1 →	+0.228	+1.765	.019	.014	3	1
UCEC	JNK2 →	+0.199	+2.348	.007	.018	3	1
UCEC	Ku80 →	+0.289	+2.920	.001	<.001	3	1
UCEC	N-Ras →	-0.112	-1.752	.012	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

eIF4G by MYC expression — UCEC

Explore this box plot interactively →