MYC

Across TCGA cell cohorts, MYC RNA expression is significantly associated with the go_rna of many other GO terms, with 4,898 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MYC-associated GO terms across cancer lineages are Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, CAMKK-AMPK signaling cascade, and Negative regulation of monocyte differentiation. Each is linked with MYC in more than 16 cancer types. Because this analysis shows association rather than direction, both MYC-to-partner and partner-to-MYC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator grouped by MYC-low versus MYC-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MYC→partner) and Y-score (partner→MYC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator →	+0.135	+1.519	<.001	<.001	3	17
BONE	CAMKK-AMPK signaling cascade →	+0.183	+1.941	<.001	<.001	3	14
LUNG_SCLC	Negative regulation of monocyte differentiation →	+1.604	+4.861	<.001	<.001	3	12
OVARY	Mitochondrial tRNA pseudouridine synthesis →	+0.133	+1.170	<.001	.001	3	12
LUNG_SCLC	tRNA wobble guanine modification →	+0.166	+3.699	<.001	<.001	3	10
LUNG_SCLC	rRNA processing →	+0.106	+4.384	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,898 associations by consensus.

Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator by MYC expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →