MYC

Across TCGA cell cohorts, MYC mutation is significantly associated with the RNA expression of many other genes, with 1,834 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MYC-associated genes across cancer lineages are FMR1NB, ZNF500, and CLASRP. Each is linked with MYC in more than 1 cancer types. Because this analysis shows association rather than direction, both MYC-to-partner and partner-to-MYC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FMR1NB grouped by MYC-low versus MYC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYC→partner) and Y-score (partner→MYC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FMR1NB →	+0.208	+3.038	<.001	.005	3	2
BLOOD_Lymphoma	ZNF500 →	+0.473	+2.074	.001	<.001	3	2
BLOOD_Lymphoma	CLASRP →	+0.450	+2.000	.006	<.001	3	2
BLOOD_Lymphoma	ATP13A1 →	+0.650	+2.874	.001	<.001	3	2
BLOOD_Lymphoma	FMO1 →	+0.452	+2.263	<.001	<.001	3	2
BLOOD_Lymphoma	TMEM39B →	+0.677	+2.874	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,834 associations by consensus.

FMR1NB by MYC expression — LARGE_INTESTINE

Explore this box plot interactively →