MYC

Across TCGA cell cohorts, MYC mutation is significantly associated with the mutation status of many other genes, with 1,394 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYC-associated genes across cancer lineages are BRSK1, TRDN, and APC2. Each is linked with MYC in more than 2 cancer types. Because this analysis shows association rather than direction, both MYC-to-partner and partner-to-MYC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRSK1 grouped by MYC-low versus MYC-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYC→partner) and Y-score (partner→MYC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	BRSK1 →	+4.977	+4.415	.007	.007	1	3
LARGE_INTESTINE	TRDN →	+2.000	+2.662	.008	.008	1	3
BLOOD_Leukemia	APC2 →	+2.817	+2.669	.001	.001	1	3
LARGE_INTESTINE	ZNF644 →	+2.777	+3.767	<.001	<.001	1	3
LARGE_INTESTINE	NAV1 →	+2.000	+4.087	<.001	<.001	1	3
LUNG_NSCLC_LUAD	GALC →	+4.339	+4.339	.009	.009	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,394 associations by consensus.

BRSK1 by MYC expression — OVARY

Explore this box plot interactively →