MYBPC3

Across TCGA patient cohorts, MYBPC3 mutation is significantly associated with the RNA expression of many other genes, with 4,415 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYBPC3-associated genes across cancer lineages are MRTO4, PSMD9, and ELP5. Each is linked with MYBPC3 in more than 4 cancer types. Because this analysis shows association rather than direction, both MYBPC3-to-partner and partner-to-MYBPC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRTO4 grouped by MYBPC3-low versus MYBPC3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYBPC3→partner) and Y-score (partner→MYBPC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MRTO4 →	+0.436	+3.511	<.001	.002	3	4
COAD	PSMD9 →	+0.329	+3.595	<.001	.001	2	5
COAD	ELP5 →	+0.385	+2.375	.001	.003	3	4
COAD	TMED2 →	+0.563	+3.026	.001	<.001	3	4
UCEC	TMEM106C →	+0.391	+2.662	.002	<.001	3	4
UCEC	TMEM62 →	+0.472	+1.895	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,415 associations by consensus.

MRTO4 by MYBPC3 expression — COAD

Explore this box plot interactively →