MYBPC3

Across TCGA patient cohorts, MYBPC3 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYBPC3-associated genes across cancer lineages are mTOR_pS2448, ATM, and C-Raf. Each is linked with MYBPC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MYBPC3-to-partner and partner-to-MYBPC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by MYBPC3-low versus MYBPC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYBPC3→partner) and Y-score (partner→MYBPC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.129	-1.717	.003	.006	3	3
UCEC	ATM →	-0.331	-1.893	.013	.014	3	3
UCEC	C-Raf →	+0.114	+1.432	.007	.005	3	3
UCEC	Cyclin-B1 →	+0.488	+2.662	.003	<.001	3	3
LUAD	A-Raf_pS299 →	+0.431	+3.169	.001	.019	3	2
UCEC	FOXO3a_pS318_S321 →	-0.100	-1.241	.006	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

mTOR_pS2448 by MYBPC3 expression — UCEC

Explore this box plot interactively →