MYBPC3

Across TCGA cell cohorts, MYBPC3 mutation is significantly associated with the RNA expression of many other genes, with 353 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYBPC3-associated genes across cancer lineages are KDSR, QARS1, and HACE1. Each is linked with MYBPC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYBPC3-to-partner and partner-to-MYBPC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KDSR grouped by MYBPC3-low versus MYBPC3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYBPC3→partner) and Y-score (partner→MYBPC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KDSR →	+0.712	+2.850	<.001	<.001	3	2
LARGE_INTESTINE	QARS1 →	+0.362	+3.321	.004	.003	3	2
LARGE_INTESTINE	HACE1 →	+0.656	+3.523	.008	<.001	3	2
OESOPHAGUS	OR8D2 →	+0.156	+4.017	<.001	.007	3	1
SOFT_TISSUE	KRT32 →	+0.167	+3.607	<.001	.006	3	1
SOFT_TISSUE	OR4X2 →	+0.018	+3.954	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 353 associations by consensus.

KDSR by MYBPC3 expression — LARGE_INTESTINE

Explore this box plot interactively →