MYBL2

Across TCGA patient cohorts, MYBL2 mutation is significantly associated with the RNA expression of many other genes, with 2,357 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYBL2-associated genes across cancer lineages are MRPL17, CHAF1B, and SAAL1. Each is linked with MYBL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MYBL2-to-partner and partner-to-MYBL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL17 grouped by MYBL2-low versus MYBL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYBL2→partner) and Y-score (partner→MYBL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL17 →	+0.303	+2.721	.001	.003	3	3
UCEC	CHAF1B →	+0.630	+2.475	<.001	<.001	3	3
SKCM	SAAL1 →	+0.552	+3.019	<.001	<.001	3	3
UCEC	SNRPD1 →	+0.346	+1.425	.006	.006	3	3
UCEC	CHAF1A →	+0.677	+2.191	<.001	<.001	3	3
UCEC	ECI1 →	+0.441	+1.654	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,357 associations by consensus.

MRPL17 by MYBL2 expression — UCEC

Explore this box plot interactively →