MYBL2

Across TCGA patient cohorts, MYBL2 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYBL2-associated genes across cancer lineages are PCNA, ERK2, and Notch1. Each is linked with MYBL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MYBL2-to-partner and partner-to-MYBL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by MYBL2-low versus MYBL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYBL2→partner) and Y-score (partner→MYBL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.250	+2.000	.001	.029	3	3
UCEC	ERK2 →	+0.176	+1.906	.009	.015	3	2
UCEC	Notch1 →	+0.162	+2.598	.001	.005	3	2
SKCM	STAT5a →	+0.531	+2.459	.045	.020	3	2
UCEC	ASNS →	+0.468	+2.415	<.001	.003	3	2
UCEC	Caspase-8 →	-0.214	-3.673	.016	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

PCNA by MYBL2 expression — UCEC

Explore this box plot interactively →