MYBL1

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, MYBL1 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYBL1-associated genes across cancer lineages are FASN, JNK_pT183_Y185, and MEK1. Each is linked with MYBL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYBL1-to-partner and partner-to-MYBL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYBL1→partner) and Y-score (partner→MYBL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECFASN →+0.389+1.584.001.00532
UCECJNK_pT183_Y185 →-0.141-1.765.007.01332
UCECMEK1 →+0.429+2.807<.001<.00132
UCECNotch1 →+0.176+2.428<.001.00132
UCECRictor_pT1135 →-0.079-1.137.014.04132
UCECAnnexin_VII →-0.128-1.990.003.00932
Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

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