MYBBP1A

Across TCGA pan-cancer cohorts, MYBBP1A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MYBBP1A data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MYBBP1A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MYBBP1A expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where MYBBP1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.600	0.878	<.001	68	view →
HNSC	DFS	Tertile	All	0.365	0.871	.014	20	view →
LSCC	OS	Quartile	All	1.000	0.662	.001	17	view →
PDAC	OS	Quartile	All	0.396	0.613	.010	15	view →
LUAD	OS	Median	All	0.999	0.920	.010	14	view →
GBM	OS	Median	All	0.647	0.404	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MYBBP1A–CCRCC (DFS)

Open the CCRCC breakdown →