MXI1

Across TCGA patient cohorts, MXI1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MXI1-associated genes across cancer lineages are Annexin-1, 14-3-3_beta, and EGFR_pY1068. Each is linked with MXI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MXI1-to-partner and partner-to-MXI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by MXI1-low versus MXI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MXI1→partner) and Y-score (partner→MXI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.633	+3.019	.007	.019	3	2
UCEC	14-3-3_beta →	-0.120	-1.986	.007	.032	3	1
UCEC	EGFR_pY1068 →	-0.330	-2.700	.003	.006	3	1
UCEC	A-Raf_pS299 →	-0.188	-3.459	<.001	.005	3	1
UCEC	ERK2 →	+0.205	+2.000	.018	.032	3	1
UCEC	JNK_pT183_Y185 →	-0.211	-2.687	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Annexin-1 by MXI1 expression — UCEC

Explore this box plot interactively →