MXI1

Across TCGA cell cohorts, MXI1 mutation is significantly associated with the mutation status of many other genes, with 2,130 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MXI1-associated genes across cancer lineages are POU2F1, ANKLE1, and PCCA. Each is linked with MXI1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MXI1-to-partner and partner-to-MXI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POU2F1 grouped by MXI1-low versus MXI1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MXI1→partner) and Y-score (partner→MXI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	POU2F1 →	+4.309	+4.560	.007	.007	1	3
BLOOD_Leukemia	ANKLE1 →	+5.894	+5.321	.002	.002	1	3
BLOOD_Leukemia	PCCA →	+4.309	+4.560	.007	.007	1	3
BLOOD_Leukemia	BAG6 →	+3.157	+4.665	.003	.003	1	3
BLOOD_Leukemia	SCRT1 →	+4.894	+4.894	.004	.004	1	3
LARGE_INTESTINE	ZFP64 →	+1.693	+3.506	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,130 associations by consensus.

POU2F1 by MXI1 expression — BLOOD_Leukemia

Explore this box plot interactively →