MXD4

Across TCGA pan-cancer cohorts, MXD4 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MXD4’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where MXD4 RNA is repressed in tumor relative to normal tissue. In most cancer types MXD4 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LIHC, and KIRC are the cancer types where MXD4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MXD4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−0.962	<.001	11	view →
LIHC	Female	II,III,IV	+1.598	<.001	9	view →
KIRC	Female	All	+0.604	<.001	7	view →
LUSC	Male	All	−0.923	<.001	6	view →
BRCA	All	II,III,IV	−0.450	<.001	6	view →
BLCA	Male	IV	−1.062	.004	4	view →
UCEC	All	All	−0.707	<.001	4	view →
READ	All	All	−0.495	.005	4	view →
CHOL	All	All	+1.956	<.001	3	view →
KICH	Male	All	−0.763	.001	3	view →
THCA	Male	II,III,IV	−0.513	.016	2	view →
HNSC	Female	All	+0.430	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MXD4–LUAD

Open the LUAD breakdown →