Across TCGA patient cohorts, MXD3 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MXD3-associated genes across cancer lineages are ERK2, A-Raf_pS299, and JNK2. Each is linked with MXD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MXD3-to-partner and partner-to-MXD3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MXD3→partner) and Y-score (partner→MXD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.186	+3.000	.038	.036	3	2
UCEC	A-Raf_pS299 →	-0.159	-3.169	.004	.019	3	1
UCEC	JNK2 →	+0.275	+3.026	.003	.018	3	1
UCEC	mTOR_pS2448 →	-0.174	-3.150	.012	.019	3	1
UCEC	Annexin-1 →	+0.516	+2.827	.035	.035	3	1
UCEC	STAT5a →	+0.378	+3.000	.042	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

MXD3 survival (RNA) · tumor vs normal (RNA) · all MXD3 data types