Across TCGA cell cohorts, MXD3 mutation is significantly associated with the mutation status of many other genes, with 198 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MXD3-associated genes across cancer lineages are ERO1B, CBFB, and ZNHIT1. Each is linked with MXD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MXD3-to-partner and partner-to-MXD3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MXD3→partner) and Y-score (partner→MXD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ERO1B →	+4.523	+5.087	.006	.006	1	2
LARGE_INTESTINE	CBFB →	+4.523	+5.087	.006	.006	1	2
LARGE_INTESTINE	ZNHIT1 →	+4.523	+5.087	.006	.006	1	2
LARGE_INTESTINE	PSMA2 →	+5.523	+5.523	.003	.003	1	2
LARGE_INTESTINE	CCNY →	+4.523	+5.087	.006	.006	1	2
LARGE_INTESTINE	NUP54 →	+4.523	+5.087	.006	.006	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 198 associations by consensus.

Exploration

MXD3 survival (RNA) · tumor vs normal (RNA) · all MXD3 data types