MXD1

Across TCGA patient cohorts, MXD1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MXD1-associated genes across cancer lineages are JNK_pT183_Y185, p27_pT198, and PCNA. Each is linked with MXD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MXD1-to-partner and partner-to-MXD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by MXD1-low versus MXD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MXD1→partner) and Y-score (partner→MXD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.186	-2.074	.004	.005	3	2
UCEC	p27_pT198 →	+0.096	+1.678	.019	.023	3	2
UCEC	PCNA →	+0.297	+2.584	<.001	.001	3	2
UCEC	Rad50 →	-0.237	-2.087	.010	.005	3	2
UCEC	c-Kit →	-0.209	-1.678	.019	.023	3	2
UCEC	EGFR_pY1068 →	-0.201	-1.678	.036	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

JNK_pT183_Y185 by MXD1 expression — UCEC

Explore this box plot interactively →