Across TCGA pan-cancer cohorts, MX2 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MX2 data layer compared with 28 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher MX2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MX2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LGG, UCEC, and ESCA are the cancer types where MX2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.129	0.812	<.001	12	view →
UCEC	DFS	Median	All	0.947	0.828	.034	8	view →
ESCA	DFS	Median	III,IV	0.103	0.442	.021	6	view →
LUAD	DFS	Median	III,IV	0.206	0.670	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: MX2 tumor-vs-normal RNA expression · all MX2 data types