Across TCGA cell cohorts, MX2 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MX2-associated genes across cancer lineages are LRRC52, FGF3, and VSTM1. Each is linked with MX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MX2-to-partner and partner-to-MX2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MX2→partner) and Y-score (partner→MX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LRRC52 →	+0.036	+4.930	<.001	.008	3	1
LUNG_SCLC	FGF3 →	+0.076	+3.584	<.001	.003	3	1
LUNG_SCLC	VSTM1 →	+1.160	+3.256	<.001	.005	3	1
LUNG_SCLC	SMIM9 →	+0.037	+3.232	.003	.008	3	1
LUNG_SCLC	GIMD1 →	+0.017	+3.232	.002	.008	3	1
BLOOD_Leukemia	PRIMA1 →	+0.033	+3.926	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

MX2 survival (RNA) · tumor vs normal (RNA) · all MX2 data types