MVP

Across TCGA patient cohorts, MVP mutation is significantly associated with the RNA expression of many other genes, with 3,956 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MVP-associated genes across cancer lineages are EIF5AL1, YARS1, and GRHPR. Each is linked with MVP in more than 3 cancer types. Because this analysis shows association rather than direction, both MVP-to-partner and partner-to-MVP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF5AL1 grouped by MVP-low versus MVP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MVP→partner) and Y-score (partner→MVP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	EIF5AL1 →	+0.851	+2.228	.002	.006	2	4
UCEC	YARS1 →	+0.455	+2.161	<.001	<.001	3	3
SKCM	GRHPR →	+0.475	+2.938	<.001	<.001	3	3
UCEC	PGAM1 →	+0.837	+2.104	<.001	<.001	3	3
UCEC	GLRX5 →	+0.287	+1.906	.006	.001	3	3
UCEC	ZNF695 →	+0.415	+3.000	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,956 associations by consensus.

EIF5AL1 by MVP expression — SKCM

Explore this box plot interactively →