MVP

Across TCGA patient cohorts, MVP mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MVP-associated genes across cancer lineages are eEF2, PCNA, and Src_pY527. Each is linked with MVP in more than 2 cancer types. Because this analysis shows association rather than direction, both MVP-to-partner and partner-to-MVP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by MVP-low versus MVP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MVP→partner) and Y-score (partner→MVP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.244	+1.874	.042	.049	3	3
UCEC	PCNA →	+0.186	+1.874	.009	.002	3	3
UCEC	Src_pY527 →	-0.289	-1.690	.045	.042	3	3
UCEC	ATM →	-0.662	-2.201	<.001	<.001	3	3
UCEC	EGFR_pY1068 →	-0.219	-2.201	.009	<.001	3	2
UCEC	INPP4B →	-0.287	-2.999	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

eEF2 by MVP expression — UCEC

Explore this box plot interactively →