MVP

Across TCGA cell cohorts, MVP RNA expression is significantly associated with the go_rna of many other GO terms, with 6,740 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MVP-associated GO terms across cancer lineages are Regulation of mononuclear cell migration, Intracellular receptor signaling pathway, and Membrane raft organization. Each is linked with MVP in more than 15 cancer types. Because this analysis shows association rather than direction, both MVP-to-partner and partner-to-MVP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mononuclear cell migration grouped by MVP-low versus MVP-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MVP→partner) and Y-score (partner→MVP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of mononuclear cell migration →	+0.160	+2.404	<.001	.001	3	16
OESOPHAGUS	Intracellular receptor signaling pathway →	+0.073	+2.917	<.001	<.001	3	16
SOFT_TISSUE	Membrane raft organization →	+0.157	+1.943	<.001	<.001	3	16
STOMACH	Response to osmotic stress →	+0.071	+1.345	<.001	.006	3	15
BONE	Protein localization to membrane →	+0.079	+2.538	<.001	<.001	3	15
STOMACH	Positive regulation of protein localization to plasma membrane →	+0.174	+2.500	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,740 associations by consensus.

Regulation of mononuclear cell migration by MVP expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →