MVP

Across TCGA cell cohorts, MVP mutation is significantly associated with the RNA expression of many other genes, with 70 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MVP-associated genes across cancer lineages are TMEM213, CST9L, and WFDC13. Each is linked with MVP in more than 1 cancer types. Because this analysis shows association rather than direction, both MVP-to-partner and partner-to-MVP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM213 grouped by MVP-low versus MVP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MVP→partner) and Y-score (partner→MVP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMEM213 →	+0.242	+3.355	.001	.007	3	2
OESOPHAGUS	CST9L →	+0.024	+3.392	<.001	.007	3	1
OESOPHAGUS	WFDC13 →	+0.082	+3.523	<.001	.009	3	1
OESOPHAGUS	OR10A4 →	+0.018	+3.857	<.001	.002	3	1
OESOPHAGUS	CYP2A13 →	+0.009	+3.392	<.001	.007	3	1
OESOPHAGUS	CELA3B →	+0.095	+3.836	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

TMEM213 by MVP expression — LARGE_INTESTINE

Explore this box plot interactively →